Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Suppressive effects of QFGJS, a preparation from an anti-arthritic herbal formula, on rat experimental adjuvant-induced arthritis

Language

English

Abstract

To analyze the anti-arthritic effects of QFGJS (a pharmaceutical preparation from herbs) on rheumatoid arthritis, adjuvant-induced arthritis (AIA) was established in male SD rats, and two administration protocols, i.e., oral treatment with different doses of QFGJS on the day of arthritis induction or on the day when visible clinical signs of arthritis occurred, were initiated and continued until day 30. Treatments with QFGJS using both administration protocols significantly suppressed the incidence and severity of arthritis in a dose-dependent manner, showing dramatic reduction of paw swelling and ESR throughout the disease progression of AIA. Radiological and histopathological examinations showed markedly decreased tissue and bone destruction of ankle joints in the QFGJS-treated rats. The serum levels of TNF-α, IL-1β, and IL-6 were significantly decreased in the QFGJS-treated rats. QFGJS demonstrates pronounced anti-arthritic effects on AIA, indicating that this herbal preparation would be a potent candidate as a novel botanical drug for further investigation. © 2005 Elsevier Inc. All rights reserved.

Keywords

Adjuvant-induced arthritis, Anti-arthritis, Herbal medicine, Pro-inflammatory cytokines, QFGJS, Rheumatoid arthritis

Publication Date

2005

Source Publication Title

Biochemical and Biophysical Research Communications

Volume

337

Issue

2

Start Page

586

End Page

594

Publisher

Elsevier

DOI

10.1016/j.bbrc.2005.09.083

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.bbrc.2005.09.083

ISSN (print)

0006291X

ISSN (electronic)

10902104

This document is currently not available here.

Share

COinS