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Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Chinese medicine formula DSQRL versus glucocorticoids for the treatment of experimental pulmonary fibrosis

Language

English

Abstract

Pulmonary fibrosis (PF) is a devastating interstitial lung disease that may develop idiopathically or as a complication of many other diseases. The outcome of the current main treatment by glucocorticoids is by no means satisfactory. This study has tested a new Chinese medicine Decoction for Strengthening Qi and Replenishing Lung (DSQRL) for the treatment of experimental PF in comparison with prednisolone. Eighty-five rats with PF induced by CCl4 were randomly divided into 4 groups to undertake treatment either by (a) high dose of prednisolone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) sham feeding of water in equal volume. At the end of 60 days treatment, the DSQRL treatment achieved a significantly better outcome than prednisolone in terms of general behavior, histological examination, hydroxyproline content of the lung and inflammatory cell counts in bronchoalveolar lavage fluid. Thus, the newly proposed Chinese medicinal formula DSQRL appears to be a better and promising option for PF than glucocorticoids for the treatment of PF. © 2008 Elsevier Ireland Ltd. All rights reserved.

Keywords

Chinese medicine, Prednisolone, Pulmonary fibrosis, Rat

Publication Date

2008

Source Publication Title

Journal of Ethnopharmacology

Volume

116

Issue

2

Start Page

318

End Page

324

Publisher

Elsevier

ISSN (print)

03788741

ISSN (electronic)

18727573

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