http://dx.doi.org/10.1016/j.jep.2006.08.016">
 

Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis

Language

English

Abstract

Pulmonary fibrosis (PF) is a restrictive lung disease that may occur idiopathically or as a complication of many diseases. The outcome of the current treatment by glucocorticoids remains very unsatisfactory. This study has tested a new Chinese medicine formula DSQRL for the treatment of experimental PF in comparison with prednisone. Seventy-two rats with PF induced by CCl4 were randomly divided into four groups to undertake the treatment of either (a) high dose of prednisone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) tap water of the same volume. At the end of 30 days treatment, the DSQRL treatment achieved a better outcome (p < 0.05) than prednisone in terms of histological examination, bronchoalveolar lavage fluid analysis, hydroxyproline assay and complications. The observations support further investigation and clinical trials of this Chinese medicinal formula for the treatment of PF. © 2006 Elsevier Ireland Ltd. All rights reserved.

Keywords

Chinese medicine, Prednisone, Pulmonary fibrosis, Rat

Publication Date

2007

Source Publication Title

Journal of Ethnopharmacology

Volume

109

Issue

3

Start Page

543

End Page

546

Publisher

Elsevier

ISSN (print)

03788741

ISSN (electronic)

18727573

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