http://dx.doi.org/10.1016/j.biomaterials.2012.09.019">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

PEG modified BaGdF5:Yb/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging

Language

English

Abstract

Herein, a multi-functional nanoprobe of polyethylene glycol (PEG) modified BaGdF5:Yb/Er upconversion nanoparticles (UCNPs) for tri-modal bioimaging of fluorescence, computed X-ray tomography (CT), and magnetic application is demonstrated for the first time. The PEG-modified BaGdF5:Yb/Er UCNPs with optimal small size were synthesized by a facile one-pot hydrothermal method. The as-designed single-phase nanoprobe presents near-infrared to visible upconversion emissions in UC fluorescent bioimaging of HeLa cell. Importantly, we have demonstrated in vivo CT images with enhanced signals of spleen of a mouse for 2 h, indicating the UCNPs can be successfully used as CT contrast agent for improving the detection of splenic diseases. In addition, these UCNPs also exhibit excellent intrinsic paramagnetic property which can be also for magnetic imaging. Therefore, our results indicate that a tri-modal nanoprobe served as fluorescent/CT/magnetic bioimaging can be realized using the PEG-modified BaGdF5:Yb/Er UCNPs with very low cytotoxicity and long circulation time, which would be very useful in a variety of biomedical application fields. © 2012 Elsevier Ltd.

Keywords

Fluorecent bio-imaging, Magnetic property, Nanoparticle, Upconversion, X-ray computed tomography

Publication Date

2012

Source Publication Title

Biomaterials

Volume

33

Issue

36

Start Page

9232

End Page

9238

Publisher

Elsevier

ISSN (print)

01429612

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