Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Tripterygium wilfordii Hook F. (TwHF) based therapy has been proved as effective in treating rheumatoid arthritis (RA), yet the predictors to its response remains unclear. A two-stage trial was designed to identify and verify the baseline symptomatic predictors of this therapy. 167 patients with active RA were enrolled with a 24-week TwHF based therapy treatment and the symptomatic predictors were identified in an open trial; then in a randomized clinical trial (RCT) for verification, 218 RA patients were enrolled and classified into predictor positive (P+) and predictor negative (Pâ ') group, and were randomly assigned to accept the TwHF based therapy and Methotrexate and Sulfasalazine combination therapy (M&S) for 24 weeks, respectively. Five predictors were identified (diuresis, excessive sweating, night sweats for positive; and yellow tongue-coating, thermalgia in the joints for negative). In the RCT, The ACR 20 responses were 82.61% in TwHF/P+ group, significantly higher than that in TwHF/Pâ ' group (P = 0.0001) and in M&S/P+ group (P < 0.05), but not higher than in M&S/Pâ ' group. Similar results were yielded in ACR 50 yet not in ACR 70 response. No significant differences were detected in safety profiles among groups. The identified predictors enable the TwHF based therapy more efficiently in treating RA subpopulations.

Publication Date

4-2015

Source Publication Title

Scientific Reports

Volume

5

Start Page

9700

Publisher

Nature Publishing Group

Peer Reviewed

1

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material.

Funder

This study was sponsored by the project from the National Eleventh Five Year Support Plan (115 Project, Project No. 2006BAI04A10) from the Ministry of Science and Technology of the People's Republic of China, and the projects from the National Science Foundation of China (Project No. 30825047).

DOI

10.1038/srep09700

Link to Publisher's Edition

http://dx.doi.org/10.1038/srep09700

ISSN (print)

20452322

Additional Files

JA-4984-27620_suppl.doc (490 kB)

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