http://dx.doi.org/10.1038/srep09700">
 

Document Type

Journal Article

Authors

Miao Jiang, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Qinglin Zha, School of Computer, Jiangxi University of Traditional Chinese Medicine
Chi Zhang, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Cheng Lu, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Xiaoping Yan, Department of Rheumatism, Beijing China-Japan Hospital
Wanhua Zhu, Nantong Liangchun Rheumatology Hospital
Wei Liu, Department of Rheumatism, First Affiliated Hospital of Tianjin University of TCM
Shenghao Tu, Department of Rheumatism, Hubei Tongji Hospital
Liping Hou, Shanxi Taiyuan Rheumatology Hospital
Chengwu Wang, Department of Rheumatism, Jilin Changchun University of TCM
Wandong Zhang, Department of Rheumatism, Anhui University of TCM
Qinghua Liang, Department of Rheumatism, Hunan Xiangya Hopital
Bing Fan, Department of Rheumatism, Shandong University of TCM
Jiangping Yu, Department of Rheumatism, Jiangxi University of TCM
Weidong Zhang, College of Pharmacy, Second Military Medical University
Xinru Liu, College of Pharmacy, Second Military Medical University
Jing Yang, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Xiaojuan He, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Li Li, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Xuyan Niu, School of Chinese Medicine, Hong Kong Baptist University
Yan Liu, School of Chinese Medicine, Hong Kong Baptist University
Hongtao Guo, Department of Rheumatism, Henan College of Chinese Medicine
Bing He, School of Chinese Medicine, Hong Kong Baptist University
Ge Zhang, School of Chinese Medicine, Hong Kong Baptist University
Zhaoxiang Bian, School of Chinese Medicine, Hong Kong Baptist University
Aiping Lu, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical SciencesFollow

Department/Unit

School of Chinese Medicine

Title

Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial

Language

English

Abstract

Tripterygium wilfordii Hook F. (TwHF) based therapy has been proved as effective in treating rheumatoid arthritis (RA), yet the predictors to its response remains unclear. A two-stage trial was designed to identify and verify the baseline symptomatic predictors of this therapy. 167 patients with active RA were enrolled with a 24-week TwHF based therapy treatment and the symptomatic predictors were identified in an open trial; then in a randomized clinical trial (RCT) for verification, 218 RA patients were enrolled and classified into predictor positive (P+) and predictor negative (Pâ ') group, and were randomly assigned to accept the TwHF based therapy and Methotrexate and Sulfasalazine combination therapy (M&S) for 24 weeks, respectively. Five predictors were identified (diuresis, excessive sweating, night sweats for positive; and yellow tongue-coating, thermalgia in the joints for negative). In the RCT, The ACR 20 responses were 82.61% in TwHF/P+ group, significantly higher than that in TwHF/Pâ ' group (P = 0.0001) and in M&S/P+ group (P < 0.05), but not higher than in M&S/Pâ ' group. Similar results were yielded in ACR 50 yet not in ACR 70 response. No significant differences were detected in safety profiles among groups. The identified predictors enable the TwHF based therapy more efficiently in treating RA subpopulations.

Publication Date

2015

Source Publication Title

Scientific Reports

Volume

5

Start Page

9700

Publisher

Nature Publishing Group

ISSN (print)

20452322

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