School of Chinese Medicine
Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities
© 2014 Springer Science+Business Media New York. A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.
8-Hydroxyquinoline, A549 cells, Antimicrobial, Aspergillus niger
Source Publication Title
Medicinal Chemistry Research
Chung, Po-Yee, Roberto Gambari, Yi-Xin Chen, Chor-Hing Cheng, Zhao-Xiang Bian, Albert Sun-Chi Chan, Johnny Cheuk-On Tang, Polly Hang-Mei Leung, Chung-Hin Chui, and Kim-Hung Lam. "Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities." Medicinal Chemistry Research 24.4 (2015): 1568-1577.