Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Language

English

Abstract

© 2014 Springer Science+Business Media New York. A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

Keywords

8-Hydroxyquinoline, A549 cells, Antimicrobial, Aspergillus niger

Publication Date

2015

Source Publication Title

Medicinal Chemistry Research

Volume

24

Issue

4

Start Page

1568

End Page

1577

Publisher

Springer

DOI

10.1007/s00044-014-1217-4

Link to Publisher's Edition

http://dx.doi.org/10.1007/s00044-014-1217-4

ISSN (print)

10542523

ISSN (electronic)

15548120

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