Document Type

Journal Article

Authors

P. L. Lam, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
S. H L Kok, School of Biomedical Sciences, Ministry of Education (MOE) Key CUHK-Jinan University Joint Laboratories, Chinese University of Hong Kong
R. Gambari, Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara
T. W. Kok, School of Biomedical Sciences, Ministry of Education (MOE) Key CUHK-Jinan University Joint Laboratories, Chinese University of Hong Kong
H. Y. Leung, School of Biomedical Sciences, Ministry of Education (MOE) Key CUHK-Jinan University Joint Laboratories, Chinese University of Hong Kong
K. L. Choi, School of Biomedical Sciences, Ministry of Education (MOE) Key CUHK-Jinan University Joint Laboratories, Chinese University of Hong Kong
C. S. Wong, School of Biomedical Sciences, Ministry of Education (MOE) Key CUHK-Jinan University Joint Laboratories, Chinese University of Hong Kong
D. K P Hau, Clinical Division, School of Chinese Medicine, Hong Kong Baptist University
W. Y. Wong, Institute of Molecular Functional Materials, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist UniversityFollow
K. H. Lam, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Z. X. Bian, Clinical Division, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
K. K H Lee, School of Biomedical Sciences, Ministry of Education (MOE) Key CUHK-Jinan University Joint Laboratories, Chinese University of Hong Kong
C. H. Chui, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic UniversityFollow

Department/Unit

School of Chinese Medicine

Title

Evaluation of berberine/bovine serum albumin nanoparticles for liver fibrosis therapy

Language

English

Abstract

© The Royal Society of Chemistry 2015. Excretion of hazardous pharmaceutical residues causes the emergence of toxic potential to the environment. Nanomedicine is commonly associated with nanoparticulate drug delivery to offer the improved therapeutic effects at a lower dose for disease treatments. Green chemistry aims to reduce or exclude the utilisation or generation of toxic substances in the design, manufacture and application of chemical products. The use of non-toxic and biodegradable materials in pharmaceutical formulations could minimize the adverse effects of pharmaceutical residues entering the environment in the first place. In our study, bovine serum albumin, a non-toxic, biodegradable and biocompatible protein, was used in the formation of nanoparticulate drug delivery systems. Glucose was used instead of glutaraldehyde to modify albumin nanoparticles for berberine delivery in order to prevent the potential toxicity to humans and the environment. These nanoparticles highly inhibited LX-2 cell growth and exhibited stronger caspase 3 activation at a lower dose when compared with free drug in vitro. Nanoparticles with berberine at doses of 1 and 2 μg g-1 could rescue mice from CCl4-induced hepatotoxicity in vivo. Green glucose-bovine serum albumin nanoparticles could be safe and effective to deliver berberine at low doses in liver fibrosis treatment.

Publication Date

2015

Source Publication Title

Green Chemistry

Volume

17

Issue

3

Start Page

1640

End Page

1646

Publisher

Royal Society of Chemistry

DOI

10.1039/c4gc01815j

Link to Publisher's Edition

http://dx.doi.org/10.1039/c4gc01815j

ISSN (print)

14639262

ISSN (electronic)

14639270

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