Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Effects of the modified Huanglian Jiedu decoction on the disease resistance in grey mullet (Mugil cephalus) to Lactococcus garvieae

Language

English

Abstract

Lactococcosis is prevalent on grey mullet (Mugil cephalus) in Hong Kong aquaculture resulting in serious economic loss. A compound formulation of Traditional Chinese Medicines (TCM) (modified Huanglian Jiedu decoction (HLJDD)) comprising Rhizoma coptidis, Radix scutellaria, Cortex phellodendri, Fructus gardeniae, Fructus forsythiae and Flos lonicerae japonicae (in a ratio of 3:2:2:3:3:5) were applied as feed supplements to deal with the disease. The Nitroblue tetrazolium activity in blood, bactericidal activity and total immunoglobulin in plasma were significantly enhanced after feeding 1% of this TCM for 28 days. The disease resistances to Lactococcus garvieae in 1% and 2% TCM feeding groups were significantly enhanced. In the in vitro study, the modified HLJDD also activated the plasma bactericidal activities (p< 0.01). Based on this study, 1% modified HLJDD feeding for 28 days may be an optimal dose to prevent L. garvieae infection and could be used in aquaculture industries. © 2014 Elsevier Ltd.

Keywords

Aquaculture, Bactericidal activity, Grey mullet, Lactococcus garvieae, Traditional Chinese Medicine

Publication Date

2014

Source Publication Title

Marine Pollution Bulletin

Volume

85

Issue

2

Start Page

816

End Page

823

Publisher

Elsevier

DOI

10.1016/j.marpolbul.2014.04.043

ISSN (print)

0025326X

ISSN (electronic)

18793363

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