Department of Chemistry; Department of Biology
A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.
Source Publication Title
Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2015
Link to Publisher's Edition
You, Qi-Hua, Yee Man Lee, Wing Hong Chan, Nai Ki Mak, Albert W. M. Lee, Sam C. K. Hau, and Thomas C. W. Mak. "A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change." RSC Advances 5.6 (2015): 4099-4102.