http://dx.doi.org/10.1039/c2ob25619c">
 

Document Type

Journal Article

Department/Unit

Department of Physics

Title

A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

Language

English

Abstract

Optical imaging provides an indispensable way to locate tumors in their early stages with high sensitivity and signal to background ratio. A heptamethine cyanine based fluorophore that emits both single photon near-infrared fluorescence and two-photon deep red fluorescence under physiological conditions was developed. Linear and nonlinear photophysical properties of this fluorophore were investigated and it demonstrated the capability to label lysosomes in cancer cells. The advantages of this fluorophore, including tolerable cytotoxicity, high fluorescence quantum yield, and the ability to emit both near-infrared single photon fluorescence and deep red two photon fluorescence in aqueous solution, give it potential to be used in intra-operatively optical image-guided tumor excision followed by two-photon fluorescence microscopy biopsy analysis after a single administration. © 2012 The Royal Society of Chemistry.

Publication Date

2012

Source Publication Title

Organic and Biomolecular Chemistry

Volume

10

Issue

28

Start Page

5366

End Page

5370

Publisher

Royal Society of Chemistry

ISSN (print)

14770520

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