Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A facile ultrasonication assisted method for Fe3O4@SiO2-Ag nanospheres with excellent antibacterial activity

Language

English

Abstract

© The Royal Society of Chemistry 2015.To increase the monodispersity of magnetic hybrid nanocomposites, a novel ultrasonic method was introduced to synthesize uniform Fe3O4@SiO2-Ag nanospheres. The immobilized Ag nanocrystals were tunable by varying the experimental conditions. An antibacterial assay indicated that the Fe3O4@SiO2-Ag nanospheres exhibited excellent antibacterial activities against Staphylococcus aureus and Escherichia coli, in which the minimum inhibition concentrations (MIC) were 40 μg mL-1 and 20 μg mL-1, respectively. The live/dead bacterial cell fluorescence stain assay agreed well with the antibacterial assay. The CCK-8 results indicated these nanospheres were bio-compatible for human normal cells and presented relative cytotoxicity against HepG2 tumor cells. These nanospheres could be easily uptaken by the cells and they could affect bacterial cells both inside and outside the cell membrane, which enable them to be promisingly applied in future biomedical areas.

Publication Date

2015

Source Publication Title

Dalton Transactions

Volume

44

Issue

19

Start Page

9140

End Page

9148

Publisher

Royal Society of Chemistry

DOI

10.1039/C5DT00977D

Link to Publisher's Edition

http://dx.doi.org/10.1039/C5DT00977D

ISSN (print)

14779226

ISSN (electronic)

14779234

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