http://dx.doi.org/10.1039/C4TB01569J">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A G-triplex luminescent switch-on probe for the detection of mung bean nuclease activity

Language

English

Abstract

© The Royal Society of Chemistry 2015.A cyclometallated Ir(III) complex was synthesised and evaluated for the ability to act as a luminescent G-triplex probe. The iridium(III) complex 1 [Ir(phq)2(2,9-dmphen)]PF6 (where phq = 2-phenylquinoline; 2,9-dmphen = 2,9-dimethyl-1,10-phenanthroline) exhibited high luminescence for G-triplex DNA over dsDNA and ssDNA, and was employed to construct a label-free G-triplex-based assay for mung bean nuclease activity in aqueous solution. This method was highly sensitive and selective for MB nuclease activity over other DNA-modifying enzymes.

Publication Date

2015

Source Publication Title

Journal of Materials Chemistry B

Volume

3

Issue

3

Start Page

348

End Page

352

Publisher

Royal Society of Chemistry

ISSN (print)

2050750X

This document is currently not available here.

Share

COinS