Department of Chemistry
Label-free luminescent switch-On probe for ochratoxin A detection using a G-quadruplex-selective Iridium(III) complex
© 2015 American Chemical Society. A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.
G-quadruplex, iridium(III) complex, label-free, luminescent, ochratoxin A
Source Publication Title
ACS Applied Materials and Interfaces
American Chemical Society
Link to Publisher's Edition
Lu, Lihua, Modi Wang, Li-Juan Liu, Chung-Hang Leung, and Dik-Lung Ma. "Label-free luminescent switch-On probe for ochratoxin A detection using a G-quadruplex-selective Iridium(III) complex." ACS Applied Materials and Interfaces 7.15 (2015): 8313-8318.