Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Label-free luminescent switch-On probe for ochratoxin A detection using a G-quadruplex-selective Iridium(III) complex

Language

English

Abstract

© 2015 American Chemical Society. A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.

Keywords

G-quadruplex, iridium(III) complex, label-free, luminescent, ochratoxin A

Publication Date

2015

Source Publication Title

ACS Applied Materials and Interfaces

Volume

7

Issue

15

Start Page

8313

End Page

8318

Publisher

American Chemical Society

DOI

10.1021/acsami.5b01702

Link to Publisher's Edition

http://dx.doi.org/10.1021/acsami.5b01702

ISSN (print)

19448244

ISSN (electronic)

19448252

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