Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Language

English

Abstract

© The Royal Society of Chemistry 2015. We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

Publication Date

2015

Source Publication Title

Chemical Communications

Volume

51

Issue

19

Start Page

3973

End Page

3976

Publisher

Royal Society of Chemistry

DOI

10.1039/C4CC09251A

Link to Publisher's Edition

http://dx.doi.org/10.1039/C4CC09251A

ISSN (print)

13597345

ISSN (electronic)

1364548X

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