http://dx.doi.org/10.1039/C4CC09251A">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Language

English

Abstract

© The Royal Society of Chemistry 2015. We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

Publication Date

2015

Source Publication Title

Chemical Communications

Volume

51

Issue

19

Start Page

3973

End Page

3976

Publisher

Royal Society of Chemistry

ISSN (print)

13597345

ISSN (electronic)

1364548X

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