Department of Chemistry
A metal-based tumour necrosis factor-alpha converting enzyme inhibitor
© The Royal Society of Chemistry 2015. We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Leung, Chung-Hang, Li-Juan Liu, Lihua Lu, Bingyong He, Daniel W. J. Kwong, Chun-Yuen Wong, and Dik-Lung Ma. "A metal-based tumour necrosis factor-alpha converting enzyme inhibitor." Chemical Communications 51.19 (2015): 3973-3976.