http://dx.doi.org/10.1016/j.jinorgbio.2014.06.020">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo

Language

English

Abstract

Metal-containing complexes have arisen as viable alternatives to organic molecules as therapeutic agents. Metal complexes possess a number of advantages compared to conventional carbon-based compounds, such as distinct geometries, interesting electronic properties, variable oxidation states and the ability to arrange different ligands around the metal centre in a precise fashion. Meanwhile, nitric oxide (NO) plays key roles in the regulation of angiogenesis, vascular permeability and inflammation. We herein report a novel cyclometalated rhodium(III) complex as an inhibitor of lipopolysaccharides (LPS)-induced NO production in RAW264.7 macrophages. Experiments suggested that the inhibition of NO production in cells by complex 1 was mediated through the down-regulation of nuclear factor-κB (NF-κB) activity. Furthermore, complex 1 inhibited angiogenesis in human umbilical vein endothelial cells (HUVECs) as revealed by an endothelial tube formation assay. This study demonstrates that kinetically inert rhodium(III) complexes may be potentially developed as effective anti-angiogenic agents. © 2014 Elsevier Inc.

Keywords

Angiogenesis, Metal complex, NF-κB, Nitric oxide, Rhodium

Publication Date

2014

Source Publication Title

Journal of Inorganic Biochemistry

Volume

140

Start Page

23

End Page

28

Publisher

Elsevier

ISSN (print)

01620134

ISSN (electronic)

18733344

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