http://dx.doi.org/10.1016/j.envpol.2014.07.032">
 

Document Type

Journal Article

Department/Unit

Department of Biology

Title

Chemical and biological characterization of air particulate matter 2.5, collected from five cities in China

Language

English

Abstract

Fifteen polycyclic aromatic hydrocarbons (PAHs) in PM2.5 samples collected in five different cities (Hong Kong (HK), Guangzhou (GZ), Xiamen (XM), Xi'an (XA) and Beijing (BJ)) in China in the winter 2012-12 were analyzed by gas chromatography-mass spectrometry. The biological effects of organic extracts were assayed using the human bronchial epithelial cells BEAS-2B. All sixteen priority PAHs can be found in the PM2.5 samples of XA and BJ, but not in HK, GZ and XM, demonstrating the differential spatial source and distribution of PAHs. Our results showed that the total PAHs ranged from 3.35 to 80.45 ng/m3 air, leading by BJ, followed by XA, XM, GZ and HK. In the cell culture study, transcript levels of pro-inflammatory cytokine interleukin-6 (IL-6), CYP1A1 and CYP1B1 were found to be induced in the treatment. The cells exposed to extracts from XA and BJ demonstrated significant migratory activities, indicating a sign of increase of tumorigenicity. © 2014 Elsevier Ltd. All rights reserved.

Keywords

Polycyclic aromatic hydrocarbons, TEF, Tumorigenicity

Publication Date

2014

Source Publication Title

Environmental Pollution

Volume

194

Start Page

188

End Page

195

Publisher

Elsevier

ISSN (print)

02697491

ISSN (electronic)

18736424

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