http://dx.doi.org/10.1016/j.bmc.2009.10.034">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Antitumor activity of diethynylfluorene derivatives of gold(I)

Language

English

Abstract

A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney. © 2009 Elsevier Ltd. All rights reserved.

Keywords

Alkynes, Fluorenes derivatives, Gold(I) complexes, Human carcinoma cells, Nude mice model, Reactive oxygen species

Publication Date

2012

Source Publication Title

Bioorganic & Medicinal Chemistry

Volume

17

Issue

23

Start Page

7872

End Page

7877

Publisher

Elsevier

ISSN (print)

09680896

ISSN (electronic)

14643391

This document is currently not available here.

Share

COinS