Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Design and synthesis of binuclear Co-salen catalysts for the hydrolytic kinetic resolution of epoxides

Language

English

Abstract

© 2015 Published by Elsevier B.V. Three binuclear Co(III)-salen complexes have been synthesized based on a series of hydrophilic cyclic frameworks with different ring sizes. The catalytic performance of Co-salen complexes have further been evaluated in the hydrolytic kinetic resolution of racemic epoxides. And kinetic studies reveal that the binuclear Co-salen catalysts show a higher reactivity and better enantioselectivity in comparison to monometallic reference complex, indicating the two Co-salen units on the cyclic framework may work in a cooperative manner. Specifically, Co3, with the most flexible cyclic framework exhibits the best catalytic performance among the three catalysts, due to the efficient cooperative interactions between two cobalt centers.

Keywords

Asymmetric catalysis, Cobalt, Kinetic resolution, Ring-opening, Salen ligands

Publication Date

2015

Source Publication Title

Catalysis Communications

Volume

68

Start Page

101

End Page

104

Publisher

Elsevier

DOI

10.1016/j.catcom.2015.05.006

ISSN (print)

15667367

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