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Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Dietary lipids and adipocytes: potential therapeutic targets in cancers

Language

English

Abstract

© 2015 Elsevier Inc.Lipids play an important role to support the rapid growth of cancer cells, which can be derived from both the endogenous synthesis and exogenous supplies. Enhanced de novo fatty acid synthesis and mobilization of stored lipids in cancer cells promote tumorigenesis. Besides, lipids and fatty acids derived from diet or transferred from neighboring adipocytes also influence the proliferation and metastasis of cancer cells. Indeed, the pathogenic roles of adipocytes in the tumor microenvironment have been recognized recently. The adipocyte-derived mediators or the cross talk between adipocytes and cancer cells in the microenvironment is gaining attention. This review will focus on the impacts of lipids on cancers and the pathogenic roles of adipocytes in tumorigenesis and discuss the possible anticancer therapeutic strategies targeting lipids in the cancer cells.

Keywords

Adipocytes, Cancer, Lipids, Microenvironment, Obesity

Publication Date

2015

Source Publication Title

Journal of Nutritional Biochemistry

Volume

26

Issue

4

Start Page

303

End Page

311

Publisher

Elsevier

ISSN (print)

09552863

ISSN (electronic)

18734847

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