Document Type

Journal Article

Department/Unit

Department of Mathematics

Title

Dissecting ancestry genomic background in substance dependence genome-wide association studies

Language

English

Abstract

© 2015 Future Medicine Ltd. Aims: To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. Materials & methods: We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes. Results: We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes. Conclusion: Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.

Keywords

African-Americans, ethnicity, European-Americans, substance dependence

Publication Date

2015

Source Publication Title

Pharmacogenomics

Volume

16

Issue

13

Start Page

1487

End Page

1498

Publisher

Future Medicine

DOI

10.2217/pgs.15.91

Link to Publisher's Edition

http://dx.doi.org/10.2217/pgs.15.91

ISSN (print)

14622416

ISSN (electronic)

17448042

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