http://dx.doi.org/10.1073/pnas.1414499111">
 

Document Type

Journal Article

Department/Unit

Office of the Vice-President (Research and Development)

Title

In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent

Language

English

Abstract

© 2014, National Academy of Sciences. All rights reserved. In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional - PDT and imaging - gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species - singlet oxygen - before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of "precision medicine" in line with stem cell and gene therapies as tools in cancer therapy.

Keywords

Gadolinium, Imaging, In vivo PDT, Survivin, Tumor recognition

Publication Date

2014

Source Publication Title

Proceedings of the National Academy of Sciences

Volume

111

Issue

51

Start Page

E5492

End Page

E5497

Publisher

National Academy of Sciences

ISSN (electronic)

10916490

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