http://dx.doi.org/10.1039/C4SC03094J">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Metal complexes as potential modulators of inflammatory and autoimmune responses

Language

English

Abstract

© The Royal Society of Chemistry 2015.Over the past few decades, the realm of inorganic medicinal chemistry has been dominated by the study of the anti-cancer properties of transition metal complexes, particularly those based on platinum or ruthenium. However, comparatively less attention has been focused on the development of metal complexes for the treatment of inflammatory or autoimmune diseases. Metal complexes possess a number of advantages that render them as attractive alternatives to organic small molecules for the development of therapeutic agents. In this perspective, we highlight recent examples in the development of transition metal complexes as modulators of inflammatory and autoimmune responses. The studies presented here serve to highlight the potential of transition metal complexes in modulating inflammatory or immune pathways in cells.

Publication Date

2015

Source Publication Title

Chemical Science

Volume

6

Issue

2

Start Page

871

End Page

884

Publisher

Royal Society of Chemistry

ISSN (print)

20416520

ISSN (electronic)

20416539

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