Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications

Language

English

Abstract

© The Royal Society of Chemistry 2015.Five water-soluble cyclen-based europium complexes incorporated with the pendant chelating chromophore, 2-methyl-4-(2-(4-propoxyphenyl)ethynyl)pyridine (L), as the antenna in different ratios have been synthesized and full structural characterization, photophysical measurement and in vitro biological studies were carried out. The antenna-to-metal ratios were 4 (Eu-4L), 3 (Eu-3L), 2 (1,4-disubstituted Eu-o-2L and 1,7-disubstituted Eu-p-2L) and 1 (Eu-1L). It was found that the definitive distinction between Eu-o-2L and Eu-p-2L could be interpreted from the emission spectra of Eu3+ at room and low temperatures. With all the results from subcellular stability testing (via titrations), in vitro imaging, cytotoxicity assays and cellular uptake profiles, Eu-4L with an overall +3 charge demonstrated subcellular localization towards lysosomes and was a potential compound for a selective time-resolved bio-labelling probe. This journal is

Publication Date

2015

Source Publication Title

RSC Advances

Volume

5

Issue

18

Start Page

13347

End Page

13356

Publisher

Royal Society of Chemistry

DOI

10.1039/C4RA16536E

Link to Publisher's Edition

http://dx.doi.org/10.1039/C4RA16536E

ISSN (electronic)

20462069

This document is currently not available here.

Share

COinS