http://dx.doi.org/10.1021/am504369b">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Visualization of Zn2+ ions in live zebrafish using a luminescent iridium(III) chemosensor

Language

English

Abstract

A novel luminescent cyclometalated iridium(III) complex-based chemosensor (1) bearing a zinc-specific receptor, tris(2-pyridylmethyl)amine, and the 3-phenyl-1H-pyrazole ligand has been designed and synthesized. Upon the addition of Zn2+ ions to a solution of iridium(III) complex 1, a pronounced luminescence color change from blue to green can be observed, which may be attributed to the suppression of photoinduced electron transfer upon complexation of complex 1 with Zn2+ ions. The interaction of iridium(III) complex 1 with Zn2+ ions was investigated by UV-vis absorption titration, emission titration, and 1H NMR titration. Furthermore, the iridium(III) complex 1 exhibited good selectivity for Zn 2+ over 13 other common metal ions, including K+, Ag +, Na+, Ni2+, Fe3+, Hg2+, Cd2+, Mg2+, Ca2+, Cu2+, Mn 2+, Co2+, and Pb2+ ions. The practical application of the iridium(III) complex 1 in visualizing intracellular Zn 2+ distribution in live zebrafish was also demonstrated. © 2014 American Chemical Society.

Keywords

chemosensor, iridium(III) complex, luminescent, zinc ion

Publication Date

2014

Source Publication Title

ACS Applied Materials and Interfaces

Volume

6

Issue

16

Start Page

14008

End Page

14015

Publisher

American Chemical Society

ISSN (print)

19448244

ISSN (electronic)

19448252

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