Department of Chemistry
In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B
We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified. © 2013 Elsevier Ltd. All rights reserved.
Amphiphilic silicon(IV) phthalocyanine, Anticancer drugs, Hep3B, Nude mice xenograft, Rhodamine B, Toxicity
Source Publication Title
Bioorganic & Medicinal Chemistry Letters
Zhao, Zhinxin, Roberto Gambari, Kenneth Ka-Ho Lee, Stanton Hon-Lung Kok, Raymond Siu-Ming Wong, Fung-Yi Lau, Johnny Cheuk-On Tang, Kim-Hung Lam, Chor-Hing Cheng, Desmond Kwok Po Hau, Chung-Hin Chui, Wai-Yeung Wong, and Wai-Kwok Wong. "In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B." Bioorganic & Medicinal Chemistry Letters 23.8 (2013): 2373-2376.