http://dx.doi.org/10.1016/j.bmcl.2013.02.049">
 

Document Type

Journal Article

Authors

Zhinxin Zhao, Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University
Roberto Gambari, BioPharmaNet, Department of Biochemistry and Molecular Biology, University of Ferrara
Kenneth Ka-Ho Lee, School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
Stanton Hon-Lung Kok, School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
Raymond Siu-Ming Wong, School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
Fung-Yi Lau, School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
Johnny Cheuk-On Tang, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Kim-Hung Lam, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Chor-Hing Cheng, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Desmond Kwok Po Hau, Clinical Division, School of Chinese Medicine, Hong Kong Baptist University
Chung-Hin Chui, School of Biomedical Sciences and Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong KongFollow
Wai-Yeung Wong, Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist UniversityFollow
Wai-Kwok Wong, Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist UniversityFollow

Department/Unit

Department of Chemistry

Title

In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Language

English

Abstract

We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified. © 2013 Elsevier Ltd. All rights reserved.

Keywords

Amphiphilic silicon(IV) phthalocyanine, Anticancer drugs, Hep3B, Nude mice xenograft, Rhodamine B, Toxicity

Publication Date

2013

Source Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume

23

Issue

8

Start Page

2373

End Page

2376

Publisher

Elsevier

ISSN (print)

0960894X

ISSN (electronic)

14643405

This document is currently not available here.

Share

COinS