School of Chinese Medicine
Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders
© 2016 by the authors; licensee MDPI, Basel, Switzerland. Abnormalities in the integral components of bone, including bone matrix, bone mineral and bone cells, give rise to complex disturbances of skeletal development, growth and homeostasis. Non-specific drug delivery using high-dose systemic administration may decrease therapeutic efficacy of drugs and increase the risk of toxic effects in non-skeletal tissues, which remain clinical challenges in the treatment of skeletal disorders. Thus, targeted delivery systems are urgently needed to achieve higher drug delivery efficiency, improve therapeutic efficacy in the targeted cells/tissues, and minimize toxicities in non-targeted cells/tissues. In this review, we summarize recent progress in the application of different targeting moieties and nanoparticles for targeted drug delivery in skeletal disorders, and also discuss the advantages, challenges and perspectives in their clinical translation.
Nanoparticles, Skeletal disorders, Targeted delivery systems, Targeting moieties
Source Publication Title
International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute
Dang, Lei, Jin Liu, Fangfei Li, Luyao Wang, Defang Li, Baosheng Guo, Xiaojuan He, Feng Jiang, Chao Liang, Biao Liu, Shaikh Atik Badshah, Bing He, Jun Lu, Cheng Lu, Aiping Lu, and Ge Zhang. "Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders." International Journal of Molecular Sciences 17.3 (2016).