Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Abnormalities in the integral components of bone, including bone matrix, bone mineral and bone cells, give rise to complex disturbances of skeletal development, growth and homeostasis. Non-specific drug delivery using high-dose systemic administration may decrease therapeutic efficacy of drugs and increase the risk of toxic effects in non-skeletal tissues, which remain clinical challenges in the treatment of skeletal disorders. Thus, targeted delivery systems are urgently needed to achieve higher drug delivery efficiency, improve therapeutic efficacy in the targeted cells/tissues, and minimize toxicities in non-targeted cells/tissues. In this review, we summarize recent progress in the application of different targeting moieties and nanoparticles for targeted drug delivery in skeletal disorders, and also discuss the advantages, challenges and perspectives in their clinical translation.

Keywords

Nanoparticles, Skeletal disorders, Targeted delivery systems, Targeting moieties

Publication Date

3-2016

Source Publication Title

International Journal of Molecular Sciences

Volume

17

Issue

3

Start Page

428

Publisher

Multidisciplinary Digital Publishing Institute

Peer Reviewed

1

Copyright

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Funder

This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang) and the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang).

DOI

10.3390/ijms17030428

Link to Publisher's Edition

http://dx.doi.org/10.3390/ijms17030428

ISSN (print)

16616596

ISSN (electronic)

14220067

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