http://dx.doi.org/10.3390/ijms17030428">
 

Document Type

Journal Article

Authors

Lei Dang, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Jin Liu, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Fangfei Li, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Luyao Wang, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Defang Li, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Baosheng Guo, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Xiaojuan He, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Feng Jiang, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Chao Liang, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Biao Liu, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Shaikh Atik Badshah, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Bing He, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Jun Lu, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Cheng Lu, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Aiping Lu, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Ge Zhang, Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow

Department/Unit

School of Chinese Medicine

Title

Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders

Language

English

Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. Abnormalities in the integral components of bone, including bone matrix, bone mineral and bone cells, give rise to complex disturbances of skeletal development, growth and homeostasis. Non-specific drug delivery using high-dose systemic administration may decrease therapeutic efficacy of drugs and increase the risk of toxic effects in non-skeletal tissues, which remain clinical challenges in the treatment of skeletal disorders. Thus, targeted delivery systems are urgently needed to achieve higher drug delivery efficiency, improve therapeutic efficacy in the targeted cells/tissues, and minimize toxicities in non-targeted cells/tissues. In this review, we summarize recent progress in the application of different targeting moieties and nanoparticles for targeted drug delivery in skeletal disorders, and also discuss the advantages, challenges and perspectives in their clinical translation.

Keywords

Nanoparticles, Skeletal disorders, Targeted delivery systems, Targeting moieties

Publication Date

2016

Source Publication Title

International Journal of Molecular Sciences

Volume

17

Issue

3

Publisher

Multidisciplinary Digital Publishing Institute

ISSN (print)

16616596

ISSN (electronic)

14220067

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