http://dx.doi.org/10.1038/srep13543">
 

Document Type

Journal Article

Department/Unit

Department of Government & International Studies

Title

A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

Language

English

Abstract

Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

Publication Date

2015

Source Publication Title

Scientific Reports

Issue

5

Publisher

Public Library of Science

ISSN (electronic)

20452322

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