Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Novel use of silymarin as delayed therapy for acetaminophen-induced acute hepatic injury

Language

English

Abstract

Aim: Recently, we have demonstrated that silymarin has a comparable pharmaceutical activity as Phyllanthus urinaria extract when used to rescue mice from acetaminophen-induced acute liver injury. In the present study, we further compared the therapeutic action of silymarin with N-acetyl cysteine (commonly used in clinical practice for emergency treatments) as a rescuer in mice after administering a lethal dose of acetaminophen for 24 h. Methods: Acute liver injury was induced in the treatment groups by intraperitoneally administered acetaminophen at a dose of 550 mg/kg body weight on day 1. The control group received an equal volume of physiological saline intraperitoneally. From day 2 to 4, the treatment groups received various doses of silymarin or N-acetyl cysteine orally once daily, while the control group and the acetaminophen group received an equal volume of water orally. The mortality rate was recorded in all groups. On day 5, all mice were sacrificed for examination. Results: Silymarin greatly improved the counteracting effects on mortality rate as compared to N-acetyl cysteine. Conclusion: Silymarin should be further considered as an antidote for patients with acetaminopheninduced acute hepatic injury and delayed treatment. © 2010 S. Karger AG.

Keywords

Acetaminophen, Hepatic injury, N-Acetyl cysteine, Silymarin

Publication Date

2010

Source Publication Title

Forschende Komplementärmedizin / Research in Complementary Medicine

Volume

17

Issue

4

Start Page

209

End Page

213

Publisher

Karger

DOI

10.1159/000319317

Link to Publisher's Edition

http://dx.doi.org/10.1159/000319317

ISSN (print)

16614119

ISSN (electronic)

16614127

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