Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Language

English

Abstract

The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent. © 2012 Elsevier GmbH. All rights reserved.

Keywords

Cancer cells, Galipea officinalis, Tetrahydroquinoline alkaloid, Xenograft

Publication Date

2013

Source Publication Title

Phytomedicine

Volume

20

Issue

2

Start Page

166

End Page

171

Publisher

Elsevier

DOI

10.1016/j.phymed.2012.09.026

ISSN (print)

09447113

ISSN (electronic)

1618095X

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