Department of Chemistry
Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents
The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent. © 2012 Elsevier GmbH. All rights reserved.
Cancer cells, Galipea officinalis, Tetrahydroquinoline alkaloid, Xenograft
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Lam, Kim-Hung, Kenneth Ka-Ho Lee, Roberto Gambari, Raymond Siu-Ming Wong, Gregory Yin-Ming Cheng, See-Wai Tong, Kit-Wah Chan, Fung-Yi Lau, Paul Bo-San Lai, Wai-Yeung Wong, Albert Sun-Chi Chan, Stanton Hon-Lung Kok, Johnny Cheuk-On Tang, and Chung-Hin Chui. "Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents." Phytomedicine 20.2 (2013): 166-171.