http://dx.doi.org/10.1071/CH08342">
 

Document Type

Journal Article

Authors

Guo-Liang Lu, Department of Chemistry, Hong Kong Baptist University
Cheuk-Lam Ho, Department of Chemistry, Hong Kong Baptist UniversityFollow
Qiwei Wang, Department of Chemistry, Hong Kong Baptist University
Wai-Yeung Wong, Department of Chemistry, Hong Kong Baptist UniversityFollow
Chung-Hin Chui, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Raymond Siu-Ming Wong, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Roberto Gambari, BioPharmaNet, Department of Biochemistry and Molecular Biology, University of Ferrara
Fung-Yi Lau, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Marcus Chun-Wah Yuen, Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University
Cindy Sze-Wai Tong, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Andrew Kit-Wah Chan, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Johnny Cheuk-On Tang, Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University
Kwok-Ping Ho, Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University
Gregory Yin-Ming Cheng, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital

Department/Unit

Department of Chemistry

Title

Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells

Language

English

Abstract

Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl 2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials. © CSIRO 2008.

Publication Date

2008

Source Publication Title

Australian Journal of Chemistry

Volume

61

Issue

12

Start Page

975

End Page

980

Publisher

CSIRO Publishing

ISSN (print)

00049425

ISSN (electronic)

14450038

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