Document Type

Journal Article

Authors

Guo-Liang Lu, Department of Chemistry, Hong Kong Baptist University
Cheuk-Lam Ho, Department of Chemistry, Hong Kong Baptist UniversityFollow
Qiwei Wang, Department of Chemistry, Hong Kong Baptist University
Wai-Yeung Wong, Department of Chemistry, Hong Kong Baptist UniversityFollow
Chung-Hin Chui, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Raymond Siu-Ming Wong, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Roberto Gambari, BioPharmaNet, Department of Biochemistry and Molecular Biology, University of Ferrara
Fung-Yi Lau, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Marcus Chun-Wah Yuen, Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University
Cindy Sze-Wai Tong, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Andrew Kit-Wah Chan, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Johnny Cheuk-On Tang, Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University
Kwok-Ping Ho, Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University
Gregory Yin-Ming Cheng, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital

Department/Unit

Department of Chemistry

Title

Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells

Language

English

Abstract

Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl 2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials. © CSIRO 2008.

Publication Date

2008

Source Publication Title

Australian Journal of Chemistry

Volume

61

Issue

12

Start Page

975

End Page

980

Publisher

CSIRO Publishing

DOI

10.1071/CH08342

Link to Publisher's Edition

http://dx.doi.org/10.1071/CH08342

ISSN (print)

00049425

ISSN (electronic)

14450038

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