Department of Chemistry
Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells
Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl 2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials. © CSIRO 2008.
Source Publication Title
Australian Journal of Chemistry
Lu, Guo-Liang, Cheuk-Lam Ho, Qiwei Wang, Wai-Yeung Wong, Chung-Hin Chui, Raymond Siu-Ming Wong, Roberto Gambari, Fung-Yi Lau, Marcus Chun-Wah Yuen, Cindy Sze-Wai Tong, Andrew Kit-Wah Chan, Johnny Cheuk-On Tang, Kwok-Ping Ho, and Gregory Yin-Ming Cheng. "Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells." Australian Journal of Chemistry 61.12 (2008): 975-980.