Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl)porphyrins

Language

English

Abstract

A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by 1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. © Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords

DNA cleavage, Photochemistry, Porphyrinoids, Sensitizers, Singlet oxygen

Publication Date

2009

Source Publication Title

European Journal of Inorganic Chemistry

Volume

2009

Issue

7

Start Page

922

End Page

928

Publisher

Wiley-VCH Verlag

DOI

10.1002/ejic.200801047

Link to Publisher's Edition

http://dx.doi.org/10.1002/ejic.200801047

ISSN (print)

14341948

ISSN (electronic)

10990682

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