Department of Chemistry
Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl)porphyrins
A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by 1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. © Wiley-VCH Verlag GmbH & Co. KGaA.
DNA cleavage, Photochemistry, Porphyrinoids, Sensitizers, Singlet oxygen
Source Publication Title
European Journal of Inorganic Chemistry
Wang, Kai, Chun-Ting Poon, Wai-Kwok Wong, Wai-Yeung Wong, Chun Y. Choi, Daniel W.J. Kwong, Heng Zhang, and Zao-Ying Li. "Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl)porphyrins." European Journal of Inorganic Chemistry 2009.7 (2009): 922-928.