Document Type

Journal Article

Department/Unit

Department of Computer Science

Title

Evaluating protein-protein interaction networks for diseases, pathway, target discoverry, and drug-design using in silico pharmacology

Language

English

Abstract

In silico pharmacology is a promising field in the current state-of drug discovery. This area exploits “proteinprotein Interaction (PPI) network analysis for drug discovery using the drug “target class”. To document the current status, we have discussed in this article how this an integrated system of PPI networks contribute to understand the disease pathways, present state-of-the-art drug target discovery and drug discovery process. This review article enhances our knowledge on conventional drug discovery and current drug discovery using in silico techniques, best “target class”, universal architecture of PPI networks, the present scenario of disease pathways and protein-protein interaction networks as well as the method to comprehend the PPI networks. Taken all together, ultimately a snapshot has been discussed to be familiar with how PPI network architecture can used to validate a drug target. At the conclusion, we have illustrated the future directions of PPI in target discovery and drug-design.

Keywords

PPI network, drug discovery

Publication Date

2014

Source Publication Title

Current Protein and Peptide Science

Volume

15

Issue

6

Start Page

561

End Page

571

Publisher

Bentham Science Publishers

DOI

10.2174/1389203715666140724090153

ISSN (print)

13892037

ISSN (electronic)

18755550

This document is currently not available here.

Share

COinS