http://dx.doi.org/10.1002/anie.201202937">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A metal-based inhibitor of tumor necrosis factor-α

Language

English

Abstract

Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

inhibitors, iridium(III) complexes, metal-based inhibitors, protein-protein interactions, tumor necrosis factor

Publication Date

2012

Source Publication Title

Angewandte Chemie International Edition

Volume

51

Issue

36

Start Page

9010

End Page

9014

Publisher

Wiley-VCH Verlag

ISSN (print)

14337851

ISSN (electronic)

15213773

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