http://dx.doi.org/10.1016/j.ccr.2013.01.034">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Bioactive iridium and rhodium complexes as therapeutic agents

Language

English

Abstract

Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded as chemically inert, studies over the past few years have demonstrated that the reactivity and biological activity of iridium and rhodium complexes may be unlocked by a suitable choice of auxiliary ligands. In addition, group 9 metal centers have received increased popularity for the construction of kinetically inert organometallic scaffolds as target-selective protein or enzyme inhibitors. In this review, we summarize the recent strategies that have been utilized for the design and development of bioactive iridium and rhodium complexes. © 2013 Elsevier B.V.

Keywords

Anti-cancer, Inorganic medicine, Iridium, Metallodrug, Rhodium

Publication Date

2013

Source Publication Title

Coordination Chemistry Reviews

Volume

257

Issue

12-11

Start Page

1764

End Page

1776

Publisher

Elsevier

ISSN (print)

00108545

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