http://dx.doi.org/10.2174/156720512802455377">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Current advancements in Aβ luminescent probes and inhibitors of Aβ aggregation

Language

English

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that severely jeopardizes the health of aging populations all over the world. According to the amyloid cascade hypothesis, the pathological progression of AD is associated with the formation of amyloid plaques in the brain, resulting from the aggregation of amyloid-β (Aβ) peptides. Over the past few years, vast efforts have been dedicated to the development of amyloid probes and inhibitors for the diagnosis and effective treatment of AD. We review here recent advancements in luminescent probes for the detection of Aβ peptide and fibrils, and the current development of small molecule inhibitors of Aβ aggregation. We also highlight the key features in each specific example, as well as review new ideas and strategies that are crucial for researchers in this field. © 2012 Bentham Science Publishers.

Keywords

Aggregation inhibitor, Alzheimer's disease, Beta-amyloid, Luminescent probe, Therapeutics agents

Publication Date

2012

Source Publication Title

Current Alzheimer Research

Volume

9

Issue

7

Start Page

830

End Page

843

Publisher

Bentham Science Publishers

ISSN (print)

15672050

ISSN (electronic)

18755828

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