Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: A theranostic agent for magnetic resonance imaging and photothermal therapy

Language

English

Abstract

In this paper, we investigated the functional imaging and targeted therapeutic properties of core@multi-shell nanoparticles composed of a superparamagnetic iron oxide (SPIO) core and gold nanorods (GNRs) in the mesoporous silica shells functionalized with folic acid (Fe3O 4@SiO2@GNRs@mSiO2-FA). The as-synthesized five-component hybrid nanocomposite was revealed to have insignificant cytotoxicity. Intracellular uptake of the nanoparticles was studied in the folate receptor over-expressing human epidermoid carcinoma of the nasopharynx (KB) cells. Due to their magnetic/optical properties as well as the folate targeting potential, compared with Fe3O4@SiO 2@GNRs@mSiO2 nanoparticles, higher cellular uptake efficiency was observed for Fe3O4@SiO 2@GNRs@mSiO2-FA nanoparticles in KB cells. Characterizations were achieved using both dark field and magnetic resonance (MR) imaging techniques. The hyperthermia induced by Fe3O 4@SiO2@GNRs@mSiO2-FA nanoparticles resulted in a higher cytotoxicity in KB cells. Thus, the Fe3O 4@SiO2@GNRs@mSiO2-FA hybrid nanomaterial is an effective and promising MR imaging and photothermal therapy agent for folate-receptor over-expressing cancer cells. © 2013 The Royal Society of Chemistry.

Publication Date

2013

Source Publication Title

Journal of Materials Chemistry. B

Volume

1

Issue

23

Start Page

2934

End Page

2942

Publisher

Royal Society of Chemistry

DOI

10.1039/C3TB20090F

Link to Publisher's Edition

http://dx.doi.org/10.1039/C3TB20090F

ISSN (print)

2050750X

This document is currently not available here.

Share

COinS