Department of Chemistry
A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe
We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.
Iridium(III) complex, Logic gate, G-quadruplex, i-motif
Source Publication Title
Science Letters Journal
Link to Publisher's Edition
Ma, Dik Lung, Modi Wang, Wanhe Wang, Lihua Lu, David Hui-Min Wang, and Chung-Hang Leung. "A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe." Science Letters Journal 4 (2015): 180.