Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe

Language

English

Abstract

We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.

Keywords

Iridium(III) complex, Logic gate, G-quadruplex, i-motif

Publication Date

2015

Source Publication Title

Science Letters Journal

Volume

4

Start Page

180

Publisher

Cognizure

ISSN (print)

24547239

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