Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an inhibitor of beta-amyloid fibrillation

Language

English

Abstract

We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

Keywords

2-acetylbenzo[b]thiophen-3-olate, Alzheimer's disease, beta-amyloid, ruthenium(II), tris(2-pyridylmethyl)amine.

Publication Date

2015

Source Publication Title

Current Alzheimer Research

Volume

12

Issue

5

Start Page

434

End Page

438

Publisher

Bentham Science Publishers

DOI

10.2174/1567205012666150504150726

ISSN (print)

15672050

ISSN (electronic)

18755828

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