Department of Chemistry
Increased efficacies in magnetofection and gene delivery to hepatocellular carcinoma cells with ternary organic–inorganic hybrid nanocomposites
A magnetic personality: Magnetofection and gene delivery have been investigated in HepG2 cells using ternary organic-inorganic hybrid nanocomposites that contain deferoxamine-coated iron oxide nanoparticles (NPs), circular plasmid DNA, and branched polyethylenimine (PEI). It was found that the cellular uptake efficacies depend on the ratio of components in PEI/DNA/NP, as assessed by Prussian staining, magnetic resonance imaging, and luciferase expression in the presence and absence of a magnet during transfection. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
gene delivery, imaging agents, magnetofection, nanoparticles, organic-inorganic hybrid composites
Source Publication Title
Chemistry - An Asian Journal
Leung, Ken Cham-Fai, Chun-Pong Chak, Siu-Fung Lee, Josie M. Y. Lai, Xiao-Ming Zhu, Yi-Xiang J. Wang, Kathy W. Y. Sham, Chi-Hin Wong, and Christopher H. K. Cheng. "Increased efficacies in magnetofection and gene delivery to hepatocellular carcinoma cells with ternary organic–inorganic hybrid nanocomposites." Chemistry - An Asian Journal 8.8 (2013): 1760-1764.