http://dx.doi.org/10.1002/asia.201300202">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Increased efficacies in magnetofection and gene delivery to hepatocellular carcinoma cells with ternary organic–inorganic hybrid nanocomposites

Language

English

Abstract

A magnetic personality: Magnetofection and gene delivery have been investigated in HepG2 cells using ternary organic-inorganic hybrid nanocomposites that contain deferoxamine-coated iron oxide nanoparticles (NPs), circular plasmid DNA, and branched polyethylenimine (PEI). It was found that the cellular uptake efficacies depend on the ratio of components in PEI/DNA/NP, as assessed by Prussian staining, magnetic resonance imaging, and luciferase expression in the presence and absence of a magnet during transfection. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

gene delivery, imaging agents, magnetofection, nanoparticles, organic-inorganic hybrid composites

Publication Date

2013

Source Publication Title

Chemistry - An Asian Journal

Volume

8

Issue

8

Start Page

1760

End Page

1764

Publisher

Wiley-VCH Verlag

ISSN (print)

18614728

ISSN (electronic)

1861471X

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