Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(III) complex

Language

English

Abstract

In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

Keywords

Amyloid, aggregation, Alzheimer's, luminescent probe, iridium

Publication Date

2015

Source Publication Title

Current Alzheimer Research

Volume

12

Issue

5

Start Page

439

End Page

444

Publisher

Bentham Science Publishers

DOI

10.2174/1567205012666150504144558

ISSN (print)

15672050

ISSN (electronic)

18755828

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