Department of Chemistry
Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study
In this paper, aiming at the trans-membrane transport properties of the different DLCs related with the cytotoxicities, we have studied photophysics of DLCs in RMs. MTT assays indicated that DLC 1 were more cytotoxic than DLC 2 and 3. Steady-state absorption and fluorescence method have been used to characterize the binding model of three DLCs (1, 2, and 3) in RMs and bovine serum albumin (BSA). The progressive red-shift of compound 1 indicated that it can experience the hydrophilic and hydrophobic environment owing to the rigid structure, thus it can more easily cross the double membrane of cell than compounds 2 and 3. In conclusion, we simulated a model of compound 1 in RMs. The present study of F16 derivatives in microenvironment would provide some useful information to the cell membrane simulation and design of DLCs. © 2012 Elsevier B.V. All rights reserved.
AOT reverse micelles, Delocalized lipophilic cations, Fluorescence method, Mitochondria
Source Publication Title
Journal of Luminescence
Li, Dong-Wei, Zu-De Qi, Xin-Liang Ding, Jia-Han Li, Feng-Lei Jiang, Yi Liu, Daniel W.J. Kwong, and Wai-Kwok Wong. "Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study." Journal of Luminescence 134 (2013): 830-836.