http://dx.doi.org/10.1021/bm301131k">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Reinforced self-assembly of donor–acceptor π-conjugated molecules to DNA templates by dipole–dipole interactions together with complementary hydrogen bonding interactions for biomimetics

Language

English

Abstract

One of the most important criteria for the successful DNA-templated polymerization to generate fully synthetic biomimetic polymers is to design the complementary structural monomers, which assemble to the templates strongly and precisely before carrying polymerization. In this study, water-soluble, laterally thymine-substituted donor-acceptor π-conjugated molecules were designed and synthesized to self-assemble with complementary oligoadenines templates, dA20 and dA40, into stable and tubular assemblies through noncovalent interactions including π-π stacking, dipole-dipole interactions, and the complementary adenine-thymine (A-T) hydrogen-bonding. UV-vis, fluorescence, circular dichroism (CD), atomic force microscopy (AFM), and transmission electron microscopy (TEM) techniques were used to investigate the formation of highly robust nanofibrous structures. Our results have demonstrated for the first time that the dipole-dipole interactions are stronger and useful to reinforce the assembly of donor-acceptor π-conjugated molecules to DNA templates and the formation of the stable and robust supramolecular nanofibrous complexes together with the complementary hydrogen bonding interactions. This provides an initial step toward DNA-templated polymerization to create fully synthetic DNA-mimetic polymers for biotechnological applications. This study also presents an opportunity to precisely position donor-acceptor type molecules in a controlled manner and tailor-make advanced materials for various biotechnological applications. © 2012 American Chemical Society.

Publication Date

2012

Source Publication Title

Biomacromolecules

Volume

13

Issue

10

Start Page

3370

End Page

3376

Publisher

American Chemical Society

ISSN (print)

15257797

ISSN (electronic)

15264602

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