Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria. The bioassay-guided fractionation and separation of the bioactive plant leads resulted in the isolation of approximately 300 compounds of varying degrees of structural complexity and/or biological activity. The present paper summarizes the significant drug discovery achievements made by the UIC-ICBG team of multidisciplinary collaborators in the project over the period of 1998–2012 and the projects carried on in the subsequent years by involving the researchers in Hong Kong.

Keywords

UIC-ICBG, bioactive compounds, drug discovery, cancer, HIV, tuberculosis, malaria

Publication Date

10-31-2016

Source Publication Title

Molecules

Volume

21

Issue

11

Start Page

1448

Publisher

MDPI

Peer Reviewed

1

Copyright

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Funder

The work was supported by the Research Grants Council of the Hong Kong Special Administrative Region (SAR), China (Project No. HKBU12103014 and HKBU12142016), the Health and Medical Research Fund of the Food and Health Bureau (HMRF), Hong Kong SAR, China (12132161), the Hong Kong Baptist University (HKBU) Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/02), Faculty Research Grant, Hong Kong Baptist University (FRG2/15-16/088 and FRG1/15-16/020) and NIH Grants 3U01TW001015-10S1 and 2U01TW001015-11A1 (administered by the Fogarty International Center as part of an International Cooperative Biodiversity Groups program, through funds from NIH, NSF, and Foreign Agricultural Service of the USDA).

DOI

10.3390/molecules21111448

Link to Publisher's Edition

http://dx.doi.org/10.3390/molecules21111448

ISSN (print)

14203049

ISSN (electronic)

14203049

Share

COinS