Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Pectins isolated from Panax ginseng C.A. Meyer are potential therapeutic agents for the treatment of diabetes mellitus, a global health challenge. Soil-to-bench procedures of ginseng pectin preparation significantly affect the polysaccharide structures. Various forms of ginseng pectins rich in homogalacturonan, rhamnogalacturonan-I, rhamnogalacturonan-II, and arabinogalactan have demonstrated independent or collaborative effects on hyperglycemia, oxidative stress, immunological dysfunction, and neoplasms. Monosaccharide compositions, peptide contents, degrees of esterification and methylation, and inter- and intramolecular linkages all influence pectin bioactivity. Understanding the preparation–structure and structure–function relationships of ginseng pectins can lead to safer and more pertinent treatment of diabetes with efficacy-oriented modifications of the pectins. To reach this goal, standardization of preparation procedures, understanding of intricate structures, and exploration of complex interactions with receptors are crucial steps to take full advantage of the medical potential of ginseng pectins.

Keywords

ginseng pectin, diabetes mellitus, homogalacturonan, rhamnogalacturonan, arabinogalactan

Publication Date

8-2017

Source Publication Title

Annals of the New York Academy of Sciences

Volume

1401

Start Page

75

End Page

89

Publisher

Wiley

Peer Reviewed

1

Copyright

This is the peer reviewed version of the following article: Chen, Q., Zhu, L., Tang, Y., Zhao, Z., Yi, T. and Chen, H. (2017), Preparation-related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins. Ann. N.Y. Acad. Sci., 1401: 75–89. doi:10.1111/nyas.13424, which has been published in final form at http://dx.doi.org/10.1111/nyas.13424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Funder

This research is funded by National Natural Science Foundation of China, grant numbers: 81603381, 81673691; Guangdong Natural Science Foundation, grant number: 2016A030313008; Shenzhen Science and Technology Innovation Committee, grant number: JCYJ20160518094706544; Faculty Research Grant of Hong Kong Baptist University, grant number: FRG2/15-16/022

DOI

10.1111/nyas.13424

Link to Publisher's Edition

http://dx.doi.org/10.1111/nyas.13424

ISSN (print)

00778923

ISSN (electronic)

17496632

Available for download on Saturday, September 01, 2018

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