Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines—particularly natural medicines—work. In many cases, the active components are generated by metabolic activation. This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated. Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo, and by decreasing oxidative stress damage. These mechanisms explain the clinical efficacy of DN as an anti-MI drug.

Keywords

Biotransformation, Intestinal microflora, Cardioprotective effects, Diosgenin, Antioxidant

Publication Date

2017

Source Publication Title

Oxidative Medicine and Cellular Longevity

Volume

2017

Start Page

Article ID 4176518

Publisher

Hindawi Publishing Corporation

Peer Reviewed

1

Copyright

Copyright © 2017 Jia-Fu Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Funder

This work was partially supported by the National Natural Science Foundation of China (81603381, 81673691) the Guangdong Natural Science Foundation (2014A030313766, 2016A030313008), the Shenzhen Science and Technology Innovation Committee (JCYJ20160518094706544), and the Faculty Research Grant of Hong Kong Baptist University (FRG2/15-16/022, FRG2/16-17/053).

DOI

10.1155/2017/4176518

Link to Publisher's Edition

http://dx.doi.org/10.1155/2017/4176518

ISSN (print)

19420900

ISSN (electronic)

19420994

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