Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.

Keywords

antibody-drug conjugates (ADCs), targeted therapy, monoclonal antibodies (mAbs), drugs, linkers

Publication Date

2-2016

Source Publication Title

International Journal of Molecular Sciences

Volume

17

Issue

2

Start Page

194

Publisher

MDPI

Peer Reviewed

1

Copyright

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Funder

This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang) and the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang).

DOI

10.3390/ijms17020194

Link to Publisher's Edition

http://dx.doi.org/10.3390/ijms17020194

ISSN (print)

16616596

ISSN (electronic)

14220067

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