Department of Chemistry
Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry
N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference. © The Royal Society of Chemistry 2012.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Gao, Xiang, Zhi Tang, Minghua Lu, Hongxia Liu, Yuyang Jiang, Yufen Zhao, and Zongwei Cai. "Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry." Chemical Communications 48.82 (2012): 10198-10200.