Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

Language

English

Abstract

N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference. © The Royal Society of Chemistry 2012.

Publication Date

2012

Source Publication Title

Chemical Communications

Volume

48

Issue

82

Start Page

10198

End Page

10200

Publisher

Royal Society of Chemistry

DOI

10.1039/C2CC36091H

Link to Publisher's Edition

http://dx.doi.org/10.1039/C2CC36091H

ISSN (print)

13597345

ISSN (electronic)

1364548X

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