Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

The genus Rosa and arthritis: Overview on pharmacological perspectives

Language

English

Abstract

The genus Rosa (roses) has long been used in traditional or folk medicine worldwide for the treatment of various types of arthritis including rheumatoid arthritis and osteoarthritis. The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-κB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-α, IL-1β, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Preclinical and clinical studies have demonstrated that these species possess analgesic, anti-arthritic, anti-inflammatory, anti-oxidative and bone-preserving activities. This review presents comprehensive overview of the mode and mechanism of action of various extracts, preparations, and active constituents from this genus. The dynamic beneficial effects of the products prepared from this genus in arthritis management are summarized. The Rosa genus is a treasure waiting for further exploration by researchers interested in the development of safe and effective anti-arthritic agents.

Keywords

Rose hips, Rosa canina, Rosa multiflora, Ursolic acid, β-sitosterol, Rheumatoid arthritis

Publication Date

12-2016

Source Publication Title

Pharmacological Research

Volume

114

Start Page

219

End Page

234

Publisher

Elsevier

Peer Reviewed

1

Copyright

© 2016 Elsevier Ltd. All rights reserved.

Funder

This work was supported by grants JCYJ20140807091945050,JCYJ20150630164505508 and JCYJ20160229210327924 from theScience, Technology and Innovation Commission of Shen-zhen, 12125116 from Research Grants Council of Hong Kong;81673649 from National Natural Science Foundation of China;2016A030313007 form Guangdong Natural Science Foundation;and FRG1/15-16/050 and FRG2/15-16/020 from the Hong KongBaptist University.

DOI

10.1016/j.phrs.2016.10.029

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.phrs.2016.10.029

ISSN (print)

10436618

ISSN (electronic)

10961186

This document is currently not available here.

Share

COinS