Department of Chemistry
A FRET fluorescent chemosensor SPAQ for Zn2+ based on a dyad bearing spiropyran and 8-aminoquinoline unit
A novel FRET fluorescent sensor SPAQ containing 8-aminoquinoline (donor) and spiropyran derivative (acceptor) was designed and synthesized for detecting Zn2+. The probe successfully exhibited a fluorescence turn on and ratiometric response for Zn2+ in ethanol solution with high selectivity. Upon excitation at 370 nm, the modulation of the emission intensity of SPAQ at 645 and 470 nm was achieved in the presence of Zn2+ by fluorescent resonance energy transfer (FRET) and chelation-enhanced fluorescence (CHEF) effects. © 2010 Elsevier Ltd. All rights reserved.
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Zhu, Jian-Fa, Han Yuan, Wing-Hong Chan, and Albert W.M. Lee. "A FRET fluorescent chemosensor SPAQ for Zn2+ based on a dyad bearing spiropyran and 8-aminoquinoline unit." Tetrahedron Letters 51.27 (2010): 3550-3554.