Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

An amphiphilic ruthenium(II)–polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

Language

English

Abstract

An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. © 2009 Elsevier Inc. All rights reserved.

Keywords

Photodynamic therapy, Porphyroid, Ru(II)-polypyridyl, Tumor-imaging, Two-photon

Publication Date

2010

Source Publication Title

Journal of Inorganic Biochemistry

Volume

104

Issue

1

Start Page

62

End Page

70

Publisher

Elsevier

DOI

10.1016/j.jinorgbio.2009.10.004

ISSN (print)

01620134

ISSN (electronic)

18733344

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