Department of Chemistry
An amphiphilic ruthenium(II)–polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent
An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. © 2009 Elsevier Inc. All rights reserved.
Photodynamic therapy, Porphyroid, Ru(II)-polypyridyl, Tumor-imaging, Two-photon
Source Publication Title
Journal of Inorganic Biochemistry
Poon, Chun-Ting, Pui-Shan Chan, Cornelia Man, Feng-Lei Jiang, Ricky Ngok Shun Wong, Nai-Ki Mak, Daniel W.J. Kwong, Sai-Wah Tsao, and Wai-Kwok Wong. "An amphiphilic ruthenium(II)–polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent." Journal of Inorganic Biochemistry 104.1 (2010): 62-70.